Research Fellow in Proteostasis

University of Leeds

Leeds, United Kingdom

Job posting number: #7081676 (Ref:FBSMB1195)

Posted: July 28, 2021

Job Description

Are you an ambitious researcher looking for your next challenge? Do you have an established background in C. elegans biology? Do you want to further your career in one of the UKs leading research intensive Universities?

We are looking for a highly motivated individual to work in collaboration with an interactive research team in the van Oosten-Hawle lab and the laboratory of Dr Michalis Barkoulas at Imperial College London. The van Oosten-Hawle lab uses the nematode C. elegans as a model system to investigate how proteostasis is maintained at the level of an entire organism throughout aging and neurodegenerative protein misfolding diseases.

Cell non-autonomous proteostasis is maintained via transcellular chaperone signalling that activates chaperone expression from one tissue to another. Using C. elegans we have identified signalling components of transcellular chaperone signalling (TCS) and the Research Fellow will investigate differences in the tissue-specific interactome of these components, define their functional basis in a cell-type specific manner and analyse the muscle-specific chromatin binding profile and transcriptome driven by a transcription factor involved in TCS.

For more information on the scientific background and Methodology, please see: Cell 153, 1366–1378 (2013); Cell Rep 23, 3905–3919 (2018); Curr Biol. 2018 Feb 19;28(4):640-648.e5. doi: 10.1016/j.cub.2018.01.029; J Vis Exp. 2020 May 16;(159). doi: 10.3791/61357.

You should have a PhD (or be close to completion) in Genetics, Cell Biology, Biochemistry or related discipline. You must be able to provide evidence of expertise in C. elegans genetics, molecular biology, fluorescence imaging and microinjection. Experience in the analysis of next generation sequencing data, statistical techniques and experience in proteomics would be an advantage.

To explore the post further or for any queries you may have, please contact:

Dr Patricija van Oosten-Hawle, Lecturer

Tel: +44 (0)113 343 30090  Email:

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Due to funding limitations it is unlikely an appointment will be made above £35,845
Working Time:  Full time (37.5 hours per week) - We will consider job share and flexible working arrangements
Post Type:  Full Time
Contract Type:  Fixed Term (for 36 months)
Release Date:  Monday 26 July 2021
Closing Date:  Tuesday 31 August 2021
Reference:  FBSMB1195

The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.

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