Job Description

ROLE SUMMARY

Pfizer Machine Learning Computational Sciences (MLCS) group has an opening for a computational methods developer with expertise in molecular modeling, Artificial Intelligence (AI), Machine Learning (ML), and scientific programming. The successful candidate will identify novel and creative applications of AI/ML and develop cutting-edge predictive and interpretable models to advance discovery and development efforts across Pfizer. This is an exciting opportunity to join a growing group of computational scientists and machine learning researchers who are passionate about developing novel computational methods and ML models to address challenging problems from early discovery to late-stage development and across established (small molecule and antibody) and emerging (mRNA therapeutics and gene therapy) therapeutic modalities.

ROLE RESPONSIBILITIES

Apply and extend the latest deep learning-based structure prediction methods to model T-cell receptors (TCR) and TCR-peptide-MHC complexes, supporting an interdisciplinary effort to explore potential therapeutic applications of TCRs.
Collaborate with colleagues from diverse scientific background to identify problems and opportunities; combine techniques from computational chemistry, computational biology, and AI/ML, particularly utilizing recent deep learning techniques, to rapidly develop powerful computational solutions.
Effectively utilize relevant public and proprietary databases and available computational resources (internal HPC and Cloud) to develop predictive models to assess pharmacological and developability properties of candidate molecules from different therapeutic modalities (small molecules, antibodies, mRNA etc).
Leverage proprietary computational framework and applications to deploy ML models and other tools for wide usage by Pfizer scientists.
Communicate and explain computational models and ML algorithms to broad scientific audience from diverse discipline.
Remain current with relevant scientific literature; proactively identify, assess, and internalize promising methods and tools from external sources.
Strengthen Pfizer’s external visibility and scientific reputation of excellence through publications in high-impact scientific journals and presentations at external conferences.
BASIC QUALIFICATIONS

Ph.D. in computational chemistry, computational biology, physical or biological sciences, chemical engineering, computer science, or related discipline.
Proficiency in Python; experience with scientific programming and algorithm design related to machine learning.
Practical hands-on experience with developing predictive models using modern deep learning techniques (e.g., CNNs and transformers) and packages (e.g., PyTorch, TensorFlow, JAX).
Track record of applying machine learning, in particular modern deep learning approaches, to solve relevant biological problems.
Proficiency in general molecular modeling techniques and familiarity with concepts, techniques, and common tools used for sequence analysis and protein structure modeling.
Experience with Unix/Linux and HPC environments.
Excellent communication and interpersonal skills.
PREFERRED QUALIFICATIONS

Strong publication record and demonstrated contribution of the machine learning field, e. g. NeurIPS, ICML, ICLR, etc.
Demonstrated track record of applying several AI/ML techniques such as ConvNet, transformers, generative modeling, and reinforcement learning to tackle complex drug discovery and development problems.
Experience in applying ML to immunology problems such as modeling of HLA-peptide and HLA-peptide-TCR structure and binding.

Additional Information:

Relocation Support Available
Eligible for employee referral
Work Location Assignment: Flexible
Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes business sense to do so.

Last Day to Apply: February 10, 2023


Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.