Molecular Oncology Postdoctoral Fellow

H. Lee Moffitt Cancer Center

Tampa, FL

Job posting number: #7219557 (Ref:75039)

Posted: February 21, 2024

Job Description

At Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 are dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women, Computerworld magazine’s list of 100 Best Places to Work in Information Technology, DiversityInc Top Hospitals & Health Systems and continually named one of the Tampa Bay Time’s Top Workplace. Additionally, Moffitt is proud to have earned the prestigious Magnet® designation in recognition of its nursing excellence. Moffitt is a National Cancer Institute-designated Comprehensive Cancer Center based in Florida, and the leading cancer hospital in both Florida and the Southeast. We are a top 10 nationally ranked cancer center by Newsweek and have been nationally ranked by U.S. News & World Report since 1999.
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join our committed team and help shape the future we envision.

Summary

Molecular Oncology Postdoctoral Fellow in the lab of Dr. Jiandong Chen

Moffitt Cancer Center and Research Institute is proud to be the first Florida’s National Cancer Institute-designated Comprehensive Cancer Center located in Tampa. We strive to be the leader in understanding the complexity of cancer through team science and applying those insights for human benefits. Every Team Member of Moffitt focuses on our lasting commitment to our mission: To contribute to the prevention and cure of cancer. 

 

The research interest of the lab is to study the structures, regulation, and therapeutic targeting of p53 tumor suppressor pathway for cancer treatment. Ongoing work involves development of novel PROTACs, targeting of temperature-sensitive mutant p53, transcription potential of mutant p53, MDMX regulation of Wnt signaling. Link to publications from Dr. Chen’s lab: 

https://www.ncbi.nlm.nih.gov/myncbi/jiandong.chen.2/bibliography/public/?sortby=pubDate&sdirection=descending

 

Position Highlights:

  • The lab has significant expertise and provides mentorship in the areas of p53/MDM2/MDMX phosphorylation signaling, ubiquitination, transcriptional regulation, and drug discovery using biochemical/cellular assays and mouse tumor models.
  • Extensive collaborations with chemists and structural biologists working in drug discovery, providing a rich environment for training and career development.
  • Moffitt integrates excellent patient care with cutting-edge clinical and basic research. Having a cancer hospital on-site provides unique opportunities for translational research.
  • Outstanding mentorship from expert faculty with wide-ranging funded research programs including T32 Training Grants.
  • You will be encouraged and supported to apply for training grants.

The Ideal Candidate:

  • With a strong background in biochemistry and molecular biology.
  • Experience with mouse tumor xenograft models or genetically modified mouse models.
  • Experience in analysis of novel drug activity and mechanisms.
  • Competent in cell culture, protein analysis, CRISPR and recombinant DNA techniques.
  • Recent PhD graduate in biochemistry or molecular biology.

Responsibilities:

  • Plans and performs experiments directed towards answering specific scientific questions with limited supervision under the general guidance of Investigator.
  • Interacts closely with Investigator and other researchers within the Investigator laboratory and conducts relevant background research including literature searches and reviews.

Credentials and Qualifications:

  • MD or PhD in biochemistry or molecular biology is required.
  • Should have at least one first author publication.

 

Moffitt Postdocs are provided with Medical Insurance (Moffitt covers premium for team members) effective upon start date and eligible for Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. You may be eligible for relocation assistance per policy. Reasons to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city, which has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is engulfed with rich culture, year-round activities for all, beautiful beaches, amazing cuisine and so much more. We strive for work/life balance.

 

If you have the vision, passion, and dedication to contribute to our mission,

then we have a place for you.

 

How to Apply: Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Chen  at [email protected]



Mission To create a Moffitt culture of diversity, equity, and inclusion as we strive to contribute to the prevention and cure of cancer. Vision To advance and accelerate a culture of access, equity, and inclusion. Diversity is a priority at Moffitt and is meant "to promote a culture of diversity and inclusion as we contribute to the prevention and cure of cancer." The Enterprise Equity Department focuses its efforts on eliminating those obstacles to an individual’s ability to exist within their personal comfort zone at the cancer center. Everyone is important to meeting this priority. Addressing and responding to diversity and inclusion fosters an environment where mutual respect for diverse cultures, communication styles, languages, customs, beliefs, values, traditions, experiences and other ways in which we identify ourselves, is the expectation.


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