Senior Computational Biologist
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7278464 (Ref:pf-4919417)
Posted: September 8, 2024
Job Description
This role is onsite/Hybrid Bothell, WA
ROLE SUMMARY:
We are looking for a Senior Computational Biologist to join our team in Pfizer’s Oncology Research Unit to apply bioinformatics and computational biology approaches to analyze, interpret and explain complex pre-clinical research data. An ideal candidate should be proficient in bulk RNA-Seq and mass spectrometry data analysis, statistics, in vitro screening and in vivo study design and analysis. Comfort working with messy data, but a passion for FAIR data is a must.
ROLE RESPONSIBILITIES:
Use RNA-seq and other omic modalities (e.g., proteomics, metabolomics, genetics, spatial transcriptomics, single-cell perturbation, epigenetics, etc.) to deliver target insights and portfolio impact.
Work in close partnership with lab-based biologists, computational biologists and bioinformaticians, machine learning scientists, statisticians and digital/IT staff.
Lead internal and external efforts to understand the tumor intrinsic and tumor microenvironment mechanisms contributing to drug sensitivity and resistance.
Drive internal teams toward the quantitative evaluation of such information for rational drug development; from in silico to in vitro to in vivo to elucidate drug efficacy and toxicity.
BASIC QUALIFICATIONS:
Ph.D. in Biological Sciences, Molecular Biology, Biochemistry, Computational Biology, or related field required; 5+ years relevant experience applying quantitative approaches to generate and address biological questions, preferably in a pharmaceutical, biotech or comparable context.
Proficient in the use of state-of-the-art tools for genomic data analysis, integration and visualization and have a solid understanding of the principles and assumptions underlying their analytical approaches.
Solid understanding of statistics, statistical approaches, and their underlying assumptions.
Ability to effectively collaborate with non-computational biologists to communicate/discuss results, hypotheses, and follow-up experiments.
Strong skills in R and Shiny application development.
Experience with FAIR data principles and data management practices.
Curiosity and initiative
PREFERRED QUALIFICATIONS:
In vivo study design and analysis.
Experience with co-fractionation mass spectrometry.
Experience and strong understanding of drug additivity models.
Preclinical oncology drug development.
Experience applying AI/ML methods to data analysis
Experience coding in R, Python, and other languages
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.